The Biochemical Dialogue Between Major Physiological Systems Mediated by Immune Cells /Dr. Fagarasan

The 8th Kyoto University Inamori Foundation Joint Kyoto Prize Symposium "Immune System Regulates Whole; Cancer, Aging, Brain, Microbiome"

“The Biochemical Dialogue Between Major Physiological Systems Mediated by Immune Cells”
Dr. Sidonia Fagarasan（Team leader, Laboratory for Mucosal Immunity, Center for Integrative Medical Sciences, RIKEN）

The evolving field of immunoregulation studies how the activity of lymphocytes is shaped by their local environment via a variety of receptor interactions with soluble and cell-bound proteins. However, small metabolites derived from metabolism of immune cells are likely present in both intracellular and extracellular milieu in vivo, many of which may have signaling potential we have yet to understand. A growing body of research addresses the flux in metabolic products produced and consumed by different immune cells in various stages of differentiation and activation. We hypothesized that water-soluble metabolites provide environmental cues which mediate interactions between immune cells and thereby regulate their functions. I will discuss how a small metabolite produced and secreted by B cells and plasma cells promotes monocyte differentiation into anti-inflammatory macrophages which secrete IL-10 and inhibit CD8+ T cell killer function and anti-tumor responses. We propose that in addition to cytokines and membrane proteins, small metabolites derived from B lineage cells have immunoregulatory functions, which may be pharmaceutical targets allowing fine-tuning of immune responses.

#KyotoPrizeSymposium　#SidoniaFagarasan　#ImmuneCells　#KyotoUniversity　#RIKEN

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The Kyoto University-Inamori Foundation Joint Kyoto Prize Symposium (KUIP) is an annual international symposium hosted by Kyoto University in cooperation with the Inamori Foundation.
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